EFHD2 Antilichaam

EFHD2 Antibody: EFHD2, also known as Swiprosin-1 or SWS1, is an EF-hand and coiled-coil-containing adaptor protein that plays a role in lymphocyte physiology. EFHD2 exhibits the highest expression in CD8+ T cells and immature B cells. It provides a membrane scaffold that is required for the Syk-, SLP-65-, and PLCgamma2-dependent B-cell receptor (BCR) -induced calcium flux. EFHD2 may also regulate BCR-induced immature and primary B-cell apoptosis. It controls spontaneous apoptosis through the regulation of BCL2L1 abundance. Also, EFHD2 plays a role as negative regulator of the canonical NF-κ B-activating branch.

79180

Q96C19

NP_077305

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Apoptosis

EFHD2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1403 - Mouse Brain Tissue Lysate

1 mg/mL

EFHD2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

EFHD2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

EFHD2

Cat. No. 10-301 - Human Brain Tissue Slide

EF-hand domain family, member D2

Homo sapiens

Kroczek C, Lang C, Brachs S, et al. Swiprosin-1/EFhd2 controls B cell receptor signaling through the assembly of the B cell receptor, Syk, and phospholipase C gamma2 in membrane rafts. J. Immunol.2010; 184:3665-76.

Avramidou A, Kroczek C, Lang C, et al. The novel adaptor protein Swiprosin-1 enhances BCR signals and contributes to BCR-induced apoptosis. Cell Death Differ.2007; 14:1936-47.

Thylur RP, Kiim YD, Kwon MS, et al. Swiprosin-1 is expressed in mast cells and up-regulated through the protein kinase C beta I/eta pathway. J. Cell Biochem.2009; 108:705-15.

EFHD2 Antibody: SWS1, SWS1, EF-hand domain-containing protein D2, Swiprosin-1

ELISA, WB, IHC-P, IF

20149675

Liquid