EGFR C797S/L858R Recombinant humaan actief eiwit Kinase

EGFR is a driver of tumorigenesis. EGFR is mainly found in an auto-inhibited, dimerization-incompetent, state at the plasma membrane (PM) . Ligand binding promotes receptor dimerization, which determines a series of structural rearrangements that are conveyed to the cytoplasmic domain allowing the formation of asymmetric dimers between the two juxtaposed catalytic domains. EGFR has multiple mutants. EGFR C797S/L858R Recombinant Human Active Protein Kinase is a recombinant EGFR C797S/L858R protein that can be used to study EGFR C797S/L858R-related functions[1].

12352211

EGFR

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Cancer

[EGFRC797S/L858RRecombinantHumanActiveProteinKinase]

[1]Sigismund S, et al. Emerging functions of the EGFR in cancer. Mol Oncol. 2018 Jan;12 (1) :3-20.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-E70696/

Enzyme

No Development Reported