EGFR d746-750/C797S Recombinant humaan actief eiwit Kinase
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
EGFR is a driver of tumorigenesis. EGFR is mainly found in an auto-inhibited, dimerization-incompetent, state at the plasma membrane (PM) . Ligand binding promotes receptor dimerization, which determines a series of structural rearrangements that are conveyed to the cytoplasmic domain allowing the formation of asymmetric dimers between the two juxtaposed catalytic domains. EGFR has multiple mutants. EGFR d746-750/C797S Recombinant Human Active Protein Kinase is a recombinant EGFR d746-750/C797S protein that can be used to study EGFR d746-750/C797S-related functions[1].
12352211
EGFR
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Cancer
[EGFRd746-750/C797SRecombinantHumanActiveProteinKinase]
[1]Sigismund S, et al. Emerging functions of the EGFR in cancer. Mol Oncol. 2018 Jan;12 (1) :3-20.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-E70698/
Enzyme
No Development Reported
Beschrijving
EGFR is a driver of tumorigenesis. EGFR is mainly found in an auto-inhibited, dimerization-incompetent, state at the plasma membrane (PM) . Ligand binding promo
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