EGFR-Fc Chimera, humaan, gezuiverd Recombinant eiwit

Epidermal Growth Factor (EGF) Receptor binds to EGF and other members of the EGF family such as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. At least 4 isoforms are produced by alternative splicing (reference SWISSPROT) . The EGF receptor is a single-pass type I membrane protein containing an extracellular receptor domain, a transmembrane region and an intracellular domain with tyrosine kinase function.

Epidermal growth factor receptor (EGFR) -Fc Chimera, purified human recombinant protein, suitable to block.

Receptor tyrosine-protein kinase erbB-1; EGFR; Urogastrone; Pro-epidermal growth factor; EGF R; c-erbB-1; ERBB1

P00533

Epidermal growth factor receptor (EGFR)

A DNA sequence encoding the signal peptide and extracellular domain of human Epidermal Growth Factor Receptor (amino acids 1-525) was fused to the Fc region of human IgG1 (amino acids 90-330) . The chimeric protein was expressed in modified human 293 cells.

Block

Purified. The EGF receptor-Fc chimera consists of 5-30% carbohydrate by weight.

When reconstituted in 0.5 mL sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose.

For research use only.

25°C (ambient)

It is recommended that 0.5 mL of sterile phosphate-buffered saline be added to the vial. Lyophilized products should be stored at 2 to 8°C. Following reconstitution short-term storage at 2-8°C is recommended, with longer-term storage in aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.

>95% purity, as determined by SDS-PAGE and visualized by Coomassie Brilliant Blue

HEK293

Lyophilized