EGFR (fosfo Thr678) Antilichaam

Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin.

1956

P00533

NP_005219.2

Human, Mouse, Rat

EGFR (Phospho-Thr678) antibody was raised against a peptide sequence around phosphorylation site of threonine 678 (K-R-T (p) -L-R) derived from Human EGFR.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

175 kDa

This antibody detects endogenous level EGFR only when phosphorylated at threonine 678.

Western Blot: 1:500~1:1000

EGFR

Epidermal growth factor receptor

Homo sapiens

Doherty JK, et al. (1999) Proc Natl Acad Sci U S A; 96 (19) : 10869-10874Wu TT, et al. (1998) Mol Biol Cell; 9 (7) : 1661-1674O’Rourke DM, et al. (1997) Proc Natl Acad Sci U S A; 94 (7) : 3250-3255Noguchi T, et al. (1994) Mol Cell Biol; 14 (10) : 6674-6682Kanner SB, et al. (1991) Mol Cell Biol; 11 (2) : 713-720

ERBB, HER1, mENA, ERBB1, PIG61, DBCN, LISX, Receptor protein-tyrosine kinase ErbB-1, kinase EGFR

WB

29725609

Liquid