EGFR G719C Recombinant humaan actief eiwit Kinase
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
EGFR is a driver of tumorigenesis. EGFR is mainly found in an auto-inhibited, dimerization-incompetent, state at the plasma membrane (PM) . Ligand binding promotes receptor dimerization, which determines a series of structural rearrangements that are conveyed to the cytoplasmic domain allowing the formation of asymmetric dimers between the two juxtaposed catalytic domains. EGFR has multiple mutants. EGFR G719C Recombinant Human Active Protein Kinase is a recombinant EGFR G719C protein that can be used to study EGFR G719C-related functions[1].
12352211
EGFR
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Cancer
[EGFRG719CRecombinantHumanActiveProteinKinase]
[1]Sigismund S, et al. Emerging functions of the EGFR in cancer. Mol Oncol. 2018 Jan;12 (1) :3-20.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-E70704/
Enzyme
No Development Reported
Beschrijving
EGFR is a driver of tumorigenesis. EGFR is mainly found in an auto-inhibited, dimerization-incompetent, state at the plasma membrane (PM) . Ligand binding promo
Specificaties
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