EGFR L858R Recombinant humaan actief eiwit Kinase

EGFR is a driver of tumorigenesis. EGFR is mainly found in an auto-inhibited, dimerization-incompetent, state at the plasma membrane (PM) . Ligand binding promotes receptor dimerization, which determines a series of structural rearrangements that are conveyed to the cytoplasmic domain allowing the formation of asymmetric dimers between the two juxtaposed catalytic domains. EGFR has multiple mutants. EGFR L858R Recombinant Human Active Protein Kinase is a recombinant EGFR L858R protein that can be used to study EGFR L858R-related functions[1].

12352211

EGFR

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Cancer

[EGFRL858RRecombinantHumanActiveProteinKinase]

[1]Sigismund S, et al. Emerging functions of the EGFR in cancer. Mol Oncol. 2018 Jan;12 (1) :3-20.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-E70707/

Enzyme

No Development Reported