EIF2S1 Antibody - C-terminal regio: FITC (ARP40508_T100-FITC)

Eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa

EIF2, EIF-2, EIF2A, EIF-2A, EIF-2alpha

1965

P05198

NP_004085

Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish

The immunogen is a synthetic peptide directed towards the C terminal region of human EIF2S1

The translation initiation factor eIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, eIF2, and GTP. eIF2 is composed of 3 nonidentical subunits, alpha (36 kD), beta (38 kD), and gamma (52 kD) . The rate of formation of the ternary complex is modulated by the phosphorylation state of eIF2-alpha.The translation initiation factor eIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, eIF2, and GTP. eIF2 is composed of 3 nonidentical subunits, alpha (36 kD), beta (38 kD, MIM 603908), and gamma (52 kD, MIM 300161) . The rate of formation of the ternary complex is modulated by the phosphorylation state of eIF2-alpha (Ernst et al., 1987) .[supplied by OMIM].

HUWE1; UBC; SUMO2; SUMO3; RPA3; RPA2; RPA1; RNF2; EIF2S3; DARS; RPS27L; EEF1E1; AIMP1; EIF2S2; RPLP0; RPL27A; RPL15; RPL13; RPL7A; QARS; MARS; MAP4; TERT; NPM1; MMS19; Dlg4; VCAM1; UPF1; ITGA4; FN1; CSNK2A1; EIF2AK2; NCOA5; POP1; STRN; YBX1; DDX1; TMED9

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

IHC, WB

0.5 mg/ml

Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 79%; Zebrafish: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

35kDa

Marciniak, S.J., (2006) J. Cell Biol. 172 (2), 201-209

Wet Ice

315

EIF2S1

EIF2S1

Rabbit

Eukaryotic translation initiation factor 2 subunit 1

NM_004094

RGVFNVQMEPKVVTDTDETELARQMERLERENAEVDGDDDAEEMEAKAED

1