EIF4EBP1 (NM 004095) Humaan Recombinant eiwit

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]

Purified recombinant protein of Human eukaryotic translation initiation factor 4E binding protein 1 (EIF4EBP1), Ser2-Ile118, with N-terminal His tag, expressed in E. coli, 50ug

4E-BP1; 4EBP1; BP-1; PHAS-I

1978

Q13541

NM_004095

8p11.23

E. coli

N-His

Acute myeloid leukemia, ErbB signaling pathway, Insulin signaling pathway, mTOR signaling pathway

Acute myeloid leukemia, ErbB signaling pathway, Insulin signaling pathway, mTOR signaling pathway

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.

12.4 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

EIF4EBP1

Human

NP_004086

https://www.ncbi.nlm.nih.gov/gene/1978

https://www.uniprot.org/uniprot/Q13541

https://www.ncbi.nlm.nih.gov/nuccore/NM_004095

https://www.ncbi.nlm.nih.gov/nuccore/NP_004086