ELAN-antilichaam

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN) . This gene is present in a gene cluster on chromosome 19.

1991

P08246

Human, Mouse

Recombinant fusion protein containing a sequence corresponding to amino acids 30-267 of human ELANE (NP_001963.1) .

Unconjugated

Primary Antibodies

Cell Cycle, Signal Transduction

Affinity purification

LO2

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 29kDa

IgG

ELANE

Mouse brain

Elastase, neutrophil expressed

Homo sapiens

ELANE, Bone marrow serine protease, ELA2, Elastase 2, neutrophil, Elastase-2, HLE, Medullasin, Granulocyte-derived elastase, Neutrophil elastase, NE, Human leukocyte elastase, PMN elastase, PMN-E, SCN1, Polymorphonuclear elastase, Elastase, neutrophil expressed, GE, Leukocyte elastase, Lysosomal elastase

WB, IF

Liquid