Elastase 3A Antilichaam / CELA3A

Elastases belong to a subfamily of serine proteases that function to catalytically hydrolyze a wide variety of proteins. Elastase-3A, also known as ELA3A or ELA3, is a 270 amino acid protein that belongs to the elastase family and acts as an alanine-specific protease. Secreted as a zymogen from the pancreas, Elastase-3A functions as a digestive enzyme in the intestine that participates in metabolic degradation pathways by preferentially cleaving proteins that have alanine residues. In addition, Elastase-3A is thought to play a role in the metabolism and transport of cholesterol molecules in the intestine. Altered expression of Elastase-3A may be associated with pancreatic ductal carcinoma, a highly fatal cancer of the pancreatic ducts

Immunohistochemistry (FFPE) : 1-2 µg/mL, Western blot: 1-2 µg/mL

P09093

Human

A portion of amino acids 50-250 from human CELA3A protein was used as the immunogen for the Elastase 3A antibody.

CELA3A/12552

IHC-P, WB

Protein G affinity

Purified

This Elastase 3A antibody is available for research use only.

Aliquot the Elastase 3A antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide

Optimal dilution of the Elastase 3A antibody should be determined by the researcher.

Cytoplasm, Extracellular space

Western blot testing of human pancreas tissue lysate with Elastase 3A antibody (clone CELA3A/12552) . Predicted molecular weight ~29 kDa.