ELF3 Antilichaam - middengebied: Biotine (ARP32247_T100-Biotine)

E74-like factor 3 (ets domain transcription factor, epithelial-specific)

ERT, ESX, EPR-1, ESE-1

1999

P78545

NP_004424

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the middle region of human ELF3

ELF3 is a novel, highly tissue-restricted member of the ets transcription factor/oncogene family. ELF3 contains two putative DNA binding domains: an ETS domain, which is unique in that the 5' half shows relatively weak homology to known ets factors, and an A/T hook domain, found in HMG proteins and various other nuclear factors. In contrast to any known ets factors, ELF3 is expressed exclusively in epithelial cells. ELF3 is expected to be a critical regulator of epithelial cell differentiation. ETS factor ELF3 is a transcriptional regulator of angiopoietin-1 gene regulation in the setting of inflammation. ELF3 overexpressed early during human breast tumorigenesis. ELF3 expression confers a transformed and in vitro metastatic phenotype to otherwise normal MCF-12A cells. ELF3 mediates the expression of TGF-beta RII, and the transcriptional inhibition of ets-related transcription factor could be a one of the mechanisms of colonic carcinogenesis. ELF3 is positively and negatively modulated by other interacting proteins including Ku70, Ku86, p300, and CBP.

MED23; XRCC5; RPL6; XRCC6; EP300; CBR3; Jun; MYC; BTRC; UBC; PAK1; TAF9; SUMO2; TBP; EPS15; CREBBP; NFKB1; EGFR; ERBB2; EHF; GANAB; ISG15; TARS; P4HB; KRT82; KRT31; JAK1; EEF1D; DDX3X; CALR; ATIC

Biotin

Polyclonal Antibody

WB

0.5 mg/ml

Cow: 86%; Dog: 93%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

41kDa

Wang, H., (2004) J. Biol. Chem. 279 (24), 25241-25250

Wet Ice

371

ELF3

ELF3

Rabbit

ETS-related transcription factor Elf-3

NM_004433

PGSCGAGAPSPGSSDVSTAGTGASRSSHSSDSGGSDVDLDPTDGKLFPSD