ELP-004
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
ELP-004 is a TRPC channel inhibitor and inhibtis TRPC channel-mediated Ca2+ entry. ELP-004 is an osteoclast inhibitor and inhibits osteoclast differentiation. ELP-004 inhibits basal Ca2+ and related NFATc1 translocation in inflammatory osteoclastogenesis. ELP-004 reduces bone erosion in a mouse model of rheumatoid arthritis[1][2].
15533-81-0
12352005
H302, H315, H319, H335
TRP Channel
Membrane Transporter/Ion Channel; Neuronal Signaling
Inflammation/Immunology
10mM
99.89
DMSO : 50 mg/mL (ultrasonic)
CCC(N(C1=CC(Cl)=C(C=C1)Cl)C)=O
C10H11Cl2NO
232.11
H302, H315, H319, H335
[1]Ray S, et al. Targeting TRPC channels for control of arthritis-induced bone erosion. Sci Adv. 2025 Jan 17;11 (3) :eabm9843.|[2]McCall JL, et al. Preclinical evaluation of ELP-004 in mice. Pharmacol Res Perspect. 2024 Aug;12 (4) :e1230.
Room Temperature
-20°C, 3 years; 4°C, 2 years (Powder)
http://file.medchemexpress.com/batch_PDF/HY-W641445/ELP-004-SDS-MedChemExpress.pdf
Reference compound1
No Development Reported
Beschrijving
ELP-004 is a TRPC channel inhibitor and inhibtis TRPC channel-mediated Ca2+ entry. ELP-004 is an osteoclast inhibitor and inhibits osteoclast differentiation. E
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