ENA-78 (8-78aa) / (CXCL5)

ENA-78 is a CXC chemokine that signals through the CXCR2 receptor. It is expressed in monocytes, platelets, endothelial cells, and mast cells. ENA-78 is a chemo attractant for neutrophils. The murine homolog of ENA-78 is called LIX. Three N-terminal truncated variants of human ENA-78; ENA 5-78, ENA 8-78, ENA 9-78, contain 74, 71, and 70 amino acid residues, respectively, possess increased biological activity. ENA-78 contains the four conserved cysteine residues present in CXC chemokines, and also contains the ‘ELR’ motif common to CXC chemokine that bind to the CXCR1 and CXCR2 receptors. Recombinant human ENA-78 is a 7.8 kDa protein consisting of 71 amino acid residues.

CXCL5; SCYB5; ENA-78

6374

P42830

NP_002985.1

NM_002994.3

4q13.3

Human

Human

LRELRCVCLQ TTQGVHPKMI SNLQVFAIGP QCSKVEVVAS LKNGKEICLD PEAPFLKKVI QKILDGGNKE N

< 0.1 ng/µg of protein (< 1EU/µg)

98% by SDS-PAGE & HPLC analyses

Determined by its ability to chemoattract human neutrophils using a concentration range of 10.0-100.0 ng/ml

71

Lyophilized

7.8 kDa

E. coli