Enterolactone-13C3

Enterolactone-13C3 is the 13C-labeled Enterolactone. Enterolactone is a bioactive phenolic metabolite known as a mammalian lignan derived from dietary lignans. Enterolactone has estrogenic properties and anti-breast cancer activity[1]. Enterolactone is a radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis[2].

918502-72-4

12352005

Apoptosis; Endogenous Metabolite; Isotope-Labeled Compounds

Apoptosis; Metabolic Enzyme/Protease; Others

Cancer

OC1=CC=CC([13CH2][C@@H]([13C](OC2)=O)[C@H]2[13CH2]C3=CC(O)=CC=C3)=C1

C15 13C3H18O4

301.31

[1]Bigdeli B, et al. Enterolactone: A novel radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis. Toxicol Appl Pharmacol. 2016;313:180-194.|[2]Mali AV, et al. Enterolactone modulates the ERK/NF-κB/Snail signaling pathway in triple-negative breast cancer cell line MDA-MB-231 to revert the TGF-β-induced epithelial-mesenchymal transition. Cancer Biol Med. 2018;15 (2) :137-156.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W778286/

Isotope-Labeled Compounds

No Development Reported