EOS006215
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
EOS006215 is a humanized monoclonal antibody inhibitor targeting TREM-2. EOS006215 reprograms TREM2+ macrophages, significantly blocks their pleiotropic pro-tumoral functions and overcomes resistance. EOS215 decreases metastasis burden in orthotopic 4T1 triple negative breast cancer mice model and significantly inhibits tumor growth in anti-PD-1 resistant mice model. EOS006215 can be used to study advanced malignant solid neoplasm, such as triple negative breast cancer (TNBC) [1].
EOS-215
12352203
TREM receptor
Immunology/Inflammation
Cancer-programmed cell death
Cancer
[1]Janss T, et al. EOS-215, a first-in-class TREM2 antagonist, designed to reprogram the tumor microenvironment and overcome resistance[J]. Cancer Research, 2025, 85 (8_Supplement_1) : 3136-3136.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-P991621/
Inhibitory Antibodies
No Development Reported
TREM-2
Beschrijving
EOS006215 is a humanized monoclonal antibody inhibitor targeting TREM-2. EOS006215 reprograms TREM2+ macrophages, significantly blocks their pleiotropic pro-tum
Specificaties
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