Eotaxine-2 (CCL24)

Eotaxin-2 is a CC chemokine that signals through the CCR3 receptor. It is produced by activated monocytes and T lymphocytes. Eotaxin-2 selectively chemo attracts cells expressing CCR3 including eosinophils, basophils, Th2 T cells, mast cells, and certain subsets of dendritic cells. Additionally, Eotaxin-2 inhibits the proliferation of multi potential hematopoietic progenitor cells. The mature protein, which also includes a C-terminal truncation, contains 78 amino acid residues (92 a.a. residues for the murine homolog, without C-terminal truncation) . Recombinant human Eotaxin-2 is an 8.8 kDa protein containing 78 amino acid residues.

CCL24; Ckb-6; MPIF2; MPIF-2; SCYA24

6369

O00175

NP_002982.2

NM_002991

7q11.23

Human

Mouse, Human, Bacteria

VVIPSPCCMF FVSKRIPENR VVSYQLSSRS TCLKGGVIFT TKKGQQFCGD PKQEWVQRYM KNLDAKQKKA SPRARAVA

< 0.1 ng/µg of protein (< 1EU/µg)

> 98% by SDS-PAGE & HPLC analyses

Determined by its ability to chemoattract using human peripheral blood eosinophils using a concentration of 50-100 ng/ml.

78

Lyophilized

8.8 kDa

E. coli