EPAC2 Antilichaam

EPAC2 Antibody: EPAC2, also known as Rap guanine nuclear exchange factor 4 and cAMPGEF-II, is belongs to a family of cyclic adenosine monophosphate (cAMP) binding proteins with guanine nucleotide exchange factor. Like the related protein EPAC1, EPAC2 signaling plays a role in numerous cellular processes such as integrin-mediated cell adhesion, muscle contraction, learning and memory, cell proliferation, and inflammation. Recent evidence suggests that EPAC2 induces synapse remodeling and depression, with mutations in its gene being found in patients with autism.

11069

Q8WZA2

NP_008954

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Signal Transduction

EPAC2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1464 - Rat Liver Tissue Lysate

1 mg/mL

EPAC2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

EPAC2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least two isoforms of EPAC2 are known to exist; this antibody will detect only the larger isoform. EPAC2 antibody is predicted to not cross-react with EPAC2

RAPGEF4

Rap guanine nucleotide exchange factor (GEF) 4

Homo sapiens

Ueno H, Shibasaki T, Iwanaga T, et al. Characterization of the gene EPAC2: structure, chromosomal localization, tissue expression, and identification of the liver-specific isoform. Genomics 2001; 78:91-8

Grandoch M, Roscioni SS, and Schmidt M. The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function. Brit. J. Pharm. 2010; 159:265-84

Holz GG, Kang G, Harbeck M, et al. Cell physiology of cAMP sensor Epac. J. Physiol. 2006; 577:5-15

EPAC2 Antibody: 2, EPAC, CGEF2, EPAC2, EPAC 2, Nbla00496, CAMP-GEFII, Rap guanine nucleotide exchange factor 4, Exchange factor directly activated by cAMP 2

ELISA, WB, IHC-P, IF

155030204

Liquid