EPHA2/5 (fosfo Tyr594) Antilichaam

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway.

1969;2044

P29317; P54756

NP_004422.2

Human, Mouse

EPHA2/5 (phospho Tyr594) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 594 (H-T-Y (p) -E-D) derived from Human EPHA2/5.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

110 kDa

IgG

The Antibody detects endogenous levels of EPHA2 only when phosphorylated at tyrosine 594.

Western Blot: 1:500~1:1000

EPHA2, EPHA5

EPH receptor A2, EPH receptor A5

Homo sapiens

Lindberg R.A., Mol. Cell. Biol. 10:6316-6324 (1990) .

Gregory S.G., Nature 441:315-321 (2006) .

ARCC2, ECK, EPHA2

WB

32967311

Liquid