EPHA4 (fosfo-Tyr596) Antilichaam

Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity.

2043

P54764

NP_004429.1

Human, Mouse

EPHA4 (phospho Tyr596) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 596 (R-T-Y (p) -V-D) derived from Human EPHA4 .

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

110 kDa

IgG

The antibody detects endogenous levels of EPHA4 only when phosphorylated at tyrosine 596

Western Blot: 1:500~1:1000

EPHA4

EPH receptor A4

Homo sapiens

Rikova K., Cell 131:1190-1203 (2007) [PubMed: 18083107].

Richter M., J. Neurosci. 27:14205-14215 (2007) [PubMed: 18094260].

Fu W.Y., Nat. Neurosci. 10:67-76 (2007) [PubMed: 17143272].

EK8, hEK8, EPH-like kinase 8

WB

1711371

Liquid