EPHA7 (fosfo-Tyr791) Antilichaam

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus.

2045

Q15375

NP_004431.1

Human, Mouse, Rat

EPHA7 (phospho Tyr791) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 791 (A-V-Y (p) -T-T) derived from Human EPHA7 .

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

112 kDa

IgG

The antibody detects endogenous levels of EPHA7only when phosphorylated at tyrosine 791.

Western Blot: 1:500~1:1000

EPHA7

EPH receptor A7

Homo sapiens

Fox G.M., Oncogene 10:897-905 (1995) .

Mungall A.J., Nature 425:805-811 (2003) .

EHK3, EK11, HEK11

WB

146345416

Liquid