Eponemycine

Eponemycin is an antibiotic that exhibits antitumor activity. Eponemycin exhibits cytotoxicity in cancer cells B16-F10, L1210, P388 and HCT-116 with IC50 of 0.0017, 0.01, 0.031 and 0.0097 µg/mL, respectively. Eponemycin inhibits the DNA synthesis in B16-F10 and Mitomycin C with IC50 of 0.1 µg/mL and 0.41 µg/mL[1].

126509-46-4

12352005

Antibiotic; DNA/RNA Synthesis

Anti-infection; Cell Cycle/DNA Damage

Cancer; Infection

CC(C)CCCCC(N[C@@H](CO)C(N[C@@H](CC(C)=C)C([C@]1(CO1)CO)=O)=O)=O

C20H34N2O6

398.49

[1]Sugawara K, et al., Eponemycin, a new antibiotic active against B16 melanoma. I. Production, isolation, structure and biological activity. J Antibiot (Tokyo) . 1990 Jan;43 (1) :8-18.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N14221/

Natural Products

No Development Reported