EPOR Antibody - N-terminal regio : HRP (ARP44216 P050-HRP)

Erythropoietin receptor

EPO-R

2057

P19235

NP_000112

Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse

The immunogen is a synthetic peptide directed towards the N terminal region of human EPOR

The erythropoietin receptor is a member of the cytokine receptor family. Upon erythropoietin binding, the erythropoietin receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis.The erythropoietin receptor is a member of the cytokine receptor family. Upon erythropoietin binding, the erythropoietin receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

PIK3R1; SRC; MST1R; JAK2; SH2B2; STAT5A; CBL; CRKL; GRB2; UBC; SOCS2; PLCG1; INPP5D; CISH; NOSIP; ATXN2L; GAB2; GAB1; GRAP; STAT5B; SOCS3; MAPK3; IRS2; SHC1; PLCG2; SYK; KITLG; GNB2L1; MAPK1; PTPN6; PTPN11; KLK3; LYN; KIT; VAV1; GNAI1; CSF2RB; EPOR; EPO

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 85%; Dog: 100%; Goat: 91%; Guinea Pig: 93%; Horse: 92%; Human: 100%; Mouse: 100%; Rat: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

53kDa

Sinclair, A.M., (2008) Br. J. Cancer 98 (6), 1059-1067

Wet Ice

508

EPOR

EPOR

Rabbit

Erythropoietin receptor

NM_000121

DHLGASLWPQVGSLCLLLAGAAWAPPPNLPDPKFESKAALLAARGPEELL