Equilin-d2

Equilin-d2 (7-Dehydroestrone-d2) is deuterium labeled Equilin. Equilin (7-Dehydroestrone) is an important member of the large group of oestrogenic substances and is chemically related to menformon (oestrone) . Equilin increases the growth of cortical neurons via an NMDA receptor-dependent mechanism[1][2].

7-Dehydroestrone-d2

12352005

Estrogen Receptor/ERR; Isotope-Labeled Compounds

Others; Vitamin D Related/Nuclear Receptor

Metabolism-protein/nucleotide metabolism

Endocrinology

C[C@]1([C@](CC2([2H])[2H])([H])C3=CCC4=C(C=CC(O)=C4)[C@@]3([H])CC1)C2=O

C18H18D2O2

270.36

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]David K, et al. Some biological properties of equilin. Biochem J. 1935;29 (2) :371-377.|[3]Brinton RD, et al. Equilin, a principal component of the estrogen replacement therapy premarin, increases the growth of cortical neurons via an NMDA receptor-dependent mechanism. Exp Neurol. 1997;147 (2) :211-220.|[4]Ito F, et al. Equilin in conjugated equine estrogen increases monocyte-endothelial adhesion via NF-κB signaling. PLoS One. 2019;14 (1) :e0211462. Published 2019 Jan 30.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B1176S1/

Isotope-Labeled Compounds

No Development Reported