ErbB 4 (ERBB4) (NM 005235) Humaan Recombinant eiwit

This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Purified recombinant protein of Human v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) (ERBB4), transcript variant JM-a/CVT-1, Arg992-End, with N-terminal His tag, expressed in E. coli, 50ug

ALS19; HER4; p180erbB4

2066

Q15303

NM_005235

2q34

E. coli

N-His

Calcium signaling pathway, Endocytosis, ErbB signaling pathway

Calcium signaling pathway, Endocytosis, ErbB signaling pathway

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.

Druggable Genome, Protein Kinase, Transmembrane

35.9 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

ERBB4

Human

NP_005226

https://www.ncbi.nlm.nih.gov/gene/2066

https://www.uniprot.org/uniprot/Q15303

https://www.ncbi.nlm.nih.gov/nuccore/NM_005235

https://www.ncbi.nlm.nih.gov/nuccore/NP_005226