ERGIC53 monoklonaal antilichaam

ERGIC53 Monoclonal Antibody: ERGIC53, also known as lectin mannose-binding 1 (LMAN1) protein is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished.

3998

NP_005561

Human, Mouse

Mouse monoclonal ERGIC53 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human ERGIC53.

Unconjugated

Primary Antibodies

Homeostasis

ERGIC53 Monoclonal Antibody is Protein A purified.

Cat. No. 1209 - HL60 Cell Lysate

1 mg/mL

ERGIC53 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

ERGIC53 Monoclonal antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Predicted: 56 kDa

IgG1

At least two isoforms of ERGIC53 are known to exist.

ERGIC53 antibody can be used for detection of ERGIC53 by Western blot at 1 - 2 μ g/mL. Antibody can also be used for immunocytochemistry starting at 5 μ g/mL.

LMAN1

Lectin, mannose-binding, 1

Homo sapiens

Schindler R, Itin C, Zerial M, et al. ERGIC-53, a membrane protein of the ER-Golgi intermediate compartment, carries an ER retention motif. Eur. J. Cell Biol. 1993; 61:1-9.

ERGIC-53 is a functional mannose-selective and calcium-dependent human homologue of leguminous lectins. Mol. Biol Cell 1996; 7:483-93

Zhang YC, Zhou Y, Yang CZ, et al. A review of ERGIC-53: its structure, functions, regulation and relations with diseases. Histol. Histopathol. 2009; 24:1193-204.

ERGIC53 Monoclonal Antibody: Lectin mannose-binding 1, LMAN1, endoplasmic reticulum-golgi intermediate compartment protein 53, ERGIC-53, F5F8D, FMFD1, MCFD1, MR60, gp58

ELISA, WB, ICC

5031873

Liquid