ERK2 Antilichaam, KO gevalideerd

This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.

5594

P28482

Human, Mouse, Rat

A synthetic peptide corresponding to a sequence within amino acids 200-300 of human ERK2 (NP_620407.1) .

Unconjugated

Primary Antibodies

Antibody is Knockout validated.

Apoptosis, Cell Cycle, Immunology, Neuroscience, Signal Transduction, Stem Cell

Affinity purification

Jurkat

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 40kDa

IgG

MAPK1

Mouse brain

Mouse liver

Mouse spleen

Rat brain

Rat spinal cord

Mitogen-activated protein kinase 1

Homo sapiens

MAPK1, ERK, p38, p40, p41, ERK2, ERT1, MAPK2, PRKM1, PRKM2, P42MAPK, p41mapk, mitogen-activated protein kinase 1, protein tyrosine kinase ERK2, mitogen-activated protein kinase 2, extracellular signal-regulated kinase 2

WB, IHC

Liquid