Ernstig basiseiwit (PRG2) (NM 002728) Humaan Recombinant eiwit

The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

Purified recombinant protein of Human proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) (PRG2), Leu17-End, with N-terminal His tag, expressed in E. coli, 50ug

BMPG; MBP; MBP1; proMBP

5553

P13727

NM_002728

11q12.1

E. coli

N-terminal His-ABP tag

Asthma

Asthma

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

50mM Tris, 8M Urea, pH8.0.

Secreted Protein

23.6 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

PRG2

Human

NP_002719

https://www.ncbi.nlm.nih.gov/gene/5553

https://www.uniprot.org/uniprot/P13727

https://www.ncbi.nlm.nih.gov/nuccore/NM_002728

https://www.ncbi.nlm.nih.gov/nuccore/NP_002719