ERVFRD-1 Polyklonale Antilichaam, APC-Cy5.5 Vervoeging

This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process (PubMed:18988732) . Endogenous envelope proteins may have kept, lost or modified their original function during evolution but this one can still make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein mediates receptor recognition, while the transmembrane protein anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (PubMed:14694139) .

EnvFRD; UNQ6191; ERVFRDE1; GLLL6191; HERV-FRD; HERV-W/FRD; Syncytin-2; Endogenous retrovirus group FRD member 1; Envelope polyprotein; HERV-FRD_6p24.1 provirus ancestral Env polyprotein; ERVFRD-1; UNQ6191/PRO20218

405754

P60508

Cell membrane

Human

331-430/538

ERVFRD-1

APC-Cy5.5

KLH conjugated synthetic peptide derived from human Syncytin-2

WB, IF (IHC-P), IF (IHC-F), IF (ICC)

Purified by Protein A.

650nm/694nm

1µg/µl

WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Unmodified

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

405754