ESR1 Antilichaam - middengebied HRP (ARP45592 P050-HRP)

Estrogen receptor 1

ER, ESR, Era, ESRA, ESTRR, NR3A1

2099

P03372

NP_000116

Human, Rat, Cow, Dog, Pig, Sheep

The immunogen is a synthetic peptide directed towards the middle region of human ESR1

Hairy/enhancer of split-related proteins, such as HEY1, are basic helix-loop-helix (bHLH) transcription factors implicated in cell fate decision and boundary formation. HEY genes are direct transcriptional targets of the Notch signaling pathways in Drosophila and vertebrates. This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.

SRC; DDX5; POLR2C; POLR2B; POLR2A; MSH2; TTC5; KAT5; NCOA2; BRCA1; MED24; UBC; PSMB9; MED1; POLR2L; POLR2K; POLR2J; POLR2I; POLR2H; POLR2G; POLR2F; POLR2E; POLR2D; ASCC1; TRRAP; PHB2; NCOR1; NCOA1; PIK3CA; IGF1R; HDAC1; NSD1; WIPI1; ESR1; ZNF131; RANBP9

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 83%; Dog: 79%; Human: 100%; Pig: 79%; Rat: 86%; Sheep: 79%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

66kDa

Giegling, I., (2008) Psychiatry Res 160 (1), 1-7

Wet Ice

595

ESR1

ESR1

Rabbit

Estrogen receptor

NM_000125

LLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAE