Estradiol-3-methylether

Estradiol 3-methyl ether is a synthetic estrogen. Estradiol 3-methyl ether can disrupt microtubule networks in V79 cells with an EC50 of 9 μM, as well as inhibiting cell proliferation. Estradiol 3-methyl ether decreases the serum cholesterol levels and increases body weight loss, which indicates feminizing activity in HFD murine model[1][2].

1035-77-4

3-O-Methyl estradiol; 17β-Estradiol 3-methyl ether; 3-Methoxyestradiol

12352211

H302+H312+H332

Biochemical Assay Reagents

Others

Endocrinology

99.93

C[C@]12CC[C@]3([H])C4=CC=C(OC)C=C4CC[C@@]3([H])[C@]1([H])CC[C@]2([H])O

C19H26O2

286.41

H302+H312+H332

[1]Aizu-Yokota, E., et al., (1995) . Natural estrogens induce modulation of microtubules in Chinese hamster V79 cells in culture. Cancer research, 55 (9), 1863–1868. |[2]R.M. Tomarelli, et al., Bioassay of Hypocholesterolemic Steroids, Journal of Pharmaceutical Sciences, Volume 55, Issue 12, 1966.

Blue Ice

-20°C, 3 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-W008581/Estradiol-3-methyl-ether-SDS-MedChemExpress.pdf

Reference compound2

No Development Reported