ETK (fosfo-Tyr566) Antilichaam

Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility.

660

P51813

NP_001712.1

Human, Mouse

ETK (phospho Tyr566) antibody was raised against a peptide sequence around phosphorylation site of Tyrosine566 (D-Q-Y (p) -V-S) derived from Human ETK.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

78 kDa

IgG

The antibody detects endogenous level of ETK only when phosphorylated at tyrosine 566.

Western Blot: 1:500~1:1000

BMX

BMX non-receptor tyrosine kinase

Homo sapiens

Zhang R, et al. (2003) J Biol Chem 278, 51267-76

Tsai YT, et al. (2000) Mol Cell Biol 20, 2043-54

BMX, BMX NON-receptor tyrosine kinase, Bone marrow kinase BMX, Epithelial and endothelial tyrosine kinase, NTK38

WB

1705489

Liquid