ETV4 Antilichaam

ETV4 Antibody: ETV4, along with the related proteins ETV1 and ETV5, form the PEA3 subfamily of the E26 transformation-specific (ETS) transcription factor family (1) . ETV4 is thought to play roles in embryonic kidney development and fertility (2,3), and is also thought to be an oncoprotein in multiple cancers (4) .

2118

P43268

NP_001977

Human, Mouse, Rat

ETV4 antibody was raised against a peptide corresponding to 19 amino acids near the amino terminus of human ETV4.

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

ETV4 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1303 - Human Brain Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Zebrafish: (72%)

ETV4 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

ETV4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least three isoforms of ETV4 are known to exist. This antibody will only detect the two longest isoforms.

ETV4

Cat. No. 1202 - A431 Cell Lysate

ETS translocation varinat 4

Homo sapiens

Xin JH, Cowie A, LAchance P, et al. Molecular cloning and characterization of PEA3, a new member of the Ets oncogene family that is differentially expressed in mouse embryonic cells. Genes Dev. 1992; 6:481-96.

Lu BC, Cebrian C, Chi X, et al. Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis. Nat. Genet. 2009; 41:1295-302.

Laing MA, Coonrod S, Hinton BT, et al. Male sexual dysfunction in mice bearing targeted mutant alleles of the PEA3 ets gene. Mol. Cell. Biol. 2000; 20:9337-45.

Oh S, Shin S, and Janknecht R. ETV1, 4 and 5: An oncogenic subfamily of ETS transcription factors. Biochim. Biophys. Acta 2012: 1826:1-12.

ETV4 Antibody: ETS variant 4, E1AF, PEA3, E1A-F, PEAS3

ELISA, WB

24307883

Liquid