Eucalbanine B

Eucalbanin B (Cornusiin A) is a dimeric tannic acid. Eucalbanin B inhibits 5α-reductase and reduces the production of dihydrotestosterone (DHT) . Eucalbanin B has anti-inflammatory properties and can inhibit the production of key pro-inflammatory cytokines (IL-6, IL-8, IL-1β, TNF-α) . Eucalbanin B has a strong inhibitory effect on the proliferation of benign prostatic hyperplasia (BPH) cell lines and can induce apoptosis in BPH cells. Eucalbanin B can be used for research on BPH[1][2].

95263-69-7

Cornusiin A

12352005

5 alpha Reductase; Apoptosis; Interleukin Related; TNF Receptor

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease

Cancer

OC1=CC(C(OC[C@@H]2[C@H]([C@H](OC(C3=CC(O)=C(O)C(O)=C3)=O)[C@@H](OC(C4=CC(O)=C(O)C(O)=C4OC5=CC(C(OC[C@@H]6[C@@H]7[C@H](OC(C8=CC(O)=C(O)C(O)=C8)=O)[C@H](C(O)O6)OC(C9=CC(O)=C(O)C(O)=C9)=O)=O)=C(C%10=C(O)C(O)=C(O)C=C%10C(O7)=O)C(O)=C5O)=O)C(O)O2)O%11)=O)=C(C%12=C(O)C(O)=C(O)C=C%12C%11=O)C(O)=C1O

C68H50O44

1571.10

[1]Park DH, et al. Inhibitory Activities of Dimeric Ellagitannins Isolated from Cornus alba on Benign Prostatic Hypertrophy. Molecules. 2021 Jun 6;26 (11) :3446.|[2]Yoshida T, et al. Chemical and Biological Significance of Oenothein B and Related Ellagitannin Oligomers with Macrocyclic Structure. Molecules. 2018 Mar 2;23 (3) :552.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N12248/

Natural Products

No Development Reported

IL-1; IL-6; IL-8