EUK-189

EUK-189 is a synthetic superoxide dismutase (SOD) and catalase mimetic. EUK-189 can block oxygen/glucose deprivation (OGD) -induced ERK1/2 dephosphorylation, ATP depletion and eliminate ROS production. EUK-189 exhibits neuroprotective effect and can inhibit delayed radiation injury. EUK-189 can be used for the research of neurological disease, such as ischemic stroke[1][2].

186350-27-6

12352100

ERK; Reactive Oxygen Species (ROS) ; SOD

Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt

Neuroscience-Neuromodulation

Neurological Disease

CC([O-][Mn+3]12([N]3=CC4=CC=CC(OCC)=C4[O-]2)[N](CC3)=CC5=C(C(OCC)=CC=C5)[O-]1)=O

C22H25MnN2O6

468.38

[1]Zhou M, et al. Superoxide dismutase/catalase mimetics but not MAP kinase inhibitors are neuroprotective against oxygen/glucose deprivation-induced neuronal death in hippocampus. J Neurochem. 2007 Dec;103 (6) :2212-23.|[2]Rosenthal RA, et al. Salen Mn complexes mitigate radiation injury in normal tissues. Anticancer Agents Med Chem. 2011 May 1;11 (4) :359-72.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-19382/

Reference compound1

Phase 1

ERK1; ERK2