Eupolauridine
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Eupolauridine (Canangine) is a selective DNA topoisomerase II inhibitor with IC50 values of 20 μM for fungal topoisomerase I and 33 μM for human topoisomerase I. Eupolauridine exerts antifungal activity by inhibiting the catalytic activity of topoisomerase II and stabilizing its cleavage complex with DNA, leading to DNA damage. Eupolauridine is promising for research of fungal infectious diseases[1][2].
58786-39-3
Canangine
12352005
Fungal; Topoisomerase
Anti-infection; Cell Cycle/DNA Damage
COVID-19-anti-virus
Infection
C1(C2=CC=CC=C23)=NC=CC4=C1C3=NC=C4
C14H8N2
204.23
[1]Khan SI, et al. Antifungal activity of eupolauridine and its action on DNA topoisomerases. Antimicrob Agents Chemother. 2002 Jun;46 (6) :1785-92.|[2]Lavanya M, et al. Synthesis and Anticancer Properties of Functionalized 1,6-Naphthyridines. Top Curr Chem (Cham) . 2021 Feb 24;379 (2) :13.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-N15319/
Natural Products
No Development Reported
Topo I; Topo II
Beschrijving
Eupolauridine (Canangine) is a selective DNA topoisomerase II inhibitor with IC50 values of 20 μM for fungal topoisomerase I and 33 μM for human topoisomerase I
Specificaties
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