EWS Antilichaam

This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t (11;22) (q24; q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.

2130

Q9BZD1

NP_053733.2

Human, Mouse, Rat

EWS antibody was raised against a peptide sequence around aa.213~217 (T-Y-G-Q-P) derived from Human EWS.

Unconjugated

Primary Antibodies

Other

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

85 kDa

This antibody detects endogenous levels of total EWS protein.

Western Blot: 1:500~1:1000

EWSR1

EWS RNA-binding protein 1

Homo sapiens

Ubhi T. B. S., Rainey D. R., Craig A. R., Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases

EWS, bK984G1.4, EWSR1

WB

253970500

Liquid