Exarafenib
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
2639957-39-2
KIN-002787, KIN-2787, RAF/KIN_2787
Raf
MAPK
C26H34F3N5O3
Exarafenib (KIN-002787, KIN-2787, RAF/KIN_2787) is an orally-available, selective inhibitor of pan-RAF. Exarafenib is effective in RAF-dependent cancers, including all classes of BRAF alterations. Exarafenib suppresses MAPK signaling in RAF-dependent melanoma cell lines. KIN-2787 exhibits low nanomolar to picomolar potency against RAF1, BRAF, and ARAF with an IC50 of 0.06-3.46 nM with minimal activity towards non-RAF kinases.
Beschrijving
Exarafenib Beschikbaar in 1 g. Bestel eenvoudig online met snelle levering.
Specificaties
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