Exodus-2 (CCL21)

Exodus-2 is a CC chemokine that signals through the CCR7 receptor. It is expressed in lymph nodes of certain endothelial cells, and in the spleen and appendix. Exodus-2 chemoattracts T and B lymphocytes and inhibits hematopoiesis. Exodus-2 contains six cysteine residues, including the four conserved cysteines present in CC chemokines. Recombinant human Exodus-2 is a 12.2 kDa protein containing 111 amino acid residues.

CCL21; ECL; SLC; CKb9; TCA4; 6Ckine; SCYA21

6366

O00585

NP_002980

NM_002989

9p13

Human

Monkey, Mouse, Human, Leech, Pig

SDGGAQDCCL KYSQRKIPAK VVRSYRKQEP SLGCSIPAIL FLPRKRSQAE LCADPKELWV QQLMQHLDKT PSPQKPAQGC RKDRGASKTG KKGKGSKGCR KTERSQTPKG P

< 0.1 ng/µg of protein (< 1EU/µg)

> 98% by SDS-PAGE & HPLC analyses

Determined by its ability to chemoattract total lymphocyte population using a concentration range of 10.0-100.0 ng/ml.

111

Lyophilized

12.2 kDa

E. coli