EXOSC4 Polyklonale Antilichaam
Gecertificeerd

EXOSC4 Polyklonale Antilichaam

Catalog #: bs-14667R
Maat: 100 µL

Kwaliteit

ISO Gecertificeerd

Levering

24-48 uur

Prijs -1%
Login voor prijs
BTW niet inbegrepen
Gratis verzending vanaf €100
Technische Documentatie

Technische Specificaties

Background

The exosome is a multisubunit complex composed of several highly conserved subunits, some of which are 3 to 5 exoribonucleases. The complex is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich (ARE) elements in their untranslated 3 region. EXOSC4 (exosome component 4), also known as SKI6, RRP41 or p12A, is a 245 amino acid protein that localizes to both the nucleus and the cytoplasm and shares 96% sequence identity with its mouse counterpart. Functioning as a component of the exosome complex, EXOSC4 exhibits 3'-5' exonuclease activity and is required for the 3'-processing of 7S pre-RNA to mature 5.8S rRNA. The gene encoding EXOSC4 maps to human chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies.

Synonyms

EXOSC 4; Exosome complex component RRP41; Exosome complex exonuclease RRP41; Exosome component 4; Exosome component Rrp41; FLJ20591; hRrp41p; p12A; EXOS4_HUMAN; Ribosomal RNA processing protein 41; RRP 41; RRP41; RRP41A; Rrp41p; SKI 6; SKI6; Ski6p.

Gene ID

54512

Swiss Prot

Q9NPD3

Cellular Locus

Cytoplasm, Nucleus

Host

• Rabbit

Cross Reactivity

Mouse

Immunogen

51-150/245

Target

EXOSC4

Clonality

• Polyclonal

Isotype

• IgG

Conjugation

Unconjugated

Source

KLH conjugated synthetic peptide derived from human EXOSC4

Applications

ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Concentration

1µg/µl

Dilution

ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Gene ID URL

54512

Predicted Cross Reactivity

Human, Rat, Dog, Cow, Sheep, Pig, Horse

Beschrijving

EXOSC4 Polyklonale Antilichaam Beschikbaar in 100 µL. Bestel eenvoudig online met snelle levering.

Specificaties

ProductnaamEXOSC4 Polyklonale Antilichaam
Categorie
Beschikbare grootte100 µL
Catalogusnummerbs-14667R