F-15845 (hydrobromide)

F 15845 hydrobromide is a highly effective persistent sodium current blocker. F 15845 hydrobromide is also a cardioprotective agent, has anti-ischemic activity and exerts short- and long-term cardioprotection after myocardial infarction. F 15845 hydrobromide can be used for the research of myocardium functional impairment[1].

866760-23-8

12352005

Sodium Channel

Membrane Transporter/Ion Channel

Cardiovascular Disease

C[C@H](CSC1=CC=CC=C1OC)CN[C@@H]2COC3=CC=CC=C3SC2.Br

C20H26BrNO2S2

456.46

[1]Bruno Vié, et al. 3- (R) -[3- (2-methoxyphenylthio-2- (S) -methylpropyl]amino-3,4-dihydro-2H-1,5-benzoxathiepine bromhydrate (F 15845) prevents ischemia-induced heart remodeling by reduction of the intracellular Na+ overload. J Pharmacol Exp Ther. 2009 Sep;330 (3) :696-703.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-19463/

Reference compound1

Phase 1