F3 Antilichaam

This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.

2152

P13726

Human, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 120-251 of human F3 (NP_001984.1) .

Unconjugated

Primary Antibodies

Immunology

Affinity purification

NCI-H460

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 45kDa

IgG

F3

SW480

HL-60

SKOV3

Coagulation factor III, tissue factor

Homo sapiens

CD142, TF, TFA, tissue factor, coagulation factor III (thromboplastin, tissue factor)

WB, IHC

Liquid