F7 Antilichaam

This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides.

2155

P08709

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 240-400 of human F7 (NP_062562.1) .

Unconjugated

Primary Antibodies

Other

Affinity purification

LO2

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 46kDa

IgG

WB: 1:500 - 1:2000

F7

293T

Jurkat

Mouse lung

Rat lung

Coagulation factor VII (serum prothrombin conversion accelerator)

Homo sapiens

F7, Coagulation factor VII, Eptacog alfa, F7 Deficiency, Factor 7, Factor VIIa, FVII coagulation protein, Factor VII, FVII, SPCA, Factor VII Deficiency, Proconvertin

WB

Liquid