FABP1 Antilichaam

Fatty acid-binding proteins, designated FABPs, are a family of homologous cytoplasmic proteins that are expressed in a highly tissue-specific manner and play an integral role in the balance between lipid and carbohydrate metabolism. FABPs mediate fatty acid (FA) and/or hydrophobic ligand uptake, transport and targeting within their respective tissues. The mechanisms underlying these actions can give rise to both passive diffusional uptake and protein-mediated transmembrane transport of FAs. FABPs are expressed in adipocytes (A-FABP), brain (B-FABP), epithelium (E-FABP, psoriasis-associated FABP, PA-FABP), striated muscle and heart (H-FABP, mammary-derived growth inhibitor or MDGI), intestine (I-FABP), liver (L-FABP or FABP1), myelin (M-FABP) and testis (T-FABP) . FABP1 (L-FABP) expression is modulated by developmental, hormonal, dietary and pharmacological factors, and is required for cholesterol synthesis and metabolism.

Western blot: 2-4 µg/mL

P07148

Human

A human partial recombinant protein (from within amino acids 1-127 was used as the immunogen for the FABP1 antibody.

FABP1/4518

WB

Protein G affinity

Purified

This FABP1 antibody is available for research use only.

Aliquot the FABP1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

1 mg/mL in 1X PBS; BSA free, sodium azide free

Optimal dilution of the FABP1 antibody should be determined by the researcher.

Cytoplasm

Western blot testing of human kidney tissue lysate with FABP1 antibody (clone FABP1/4518) . Predicted molecular weight ~15 kDa.