FABP1 Antilichaam

Fatty acid-binding proteins, designated FABPs, are a family of homologous cytoplasmic proteins that are expressed in a highly tissue-specific manner and play an integral role in the balance between lipid and carbohydrate metabolism. FABPs mediate fatty acid (FA) and/or hydrophobic ligand uptake, transport and targeting within their respective tissues. The mechanisms underlying these actions can give rise to both passive diffusional uptake and protein-mediated transmembrane transport of FAs. FABPs are expressed in adipocytes (A-FABP), brain (B-FABP), epithelium (E-FABP, psoriasis-associated FABP, PA-FABP), striated muscle and heart (H-FABP, mammary-derived growth inhibitor or MDGI), intestine (I-FABP), liver (L-FABP or FABP1), myelin (M-FABP) and testis (T-FABP) . FABP1 (L-FABP) expression is modulated by developmental, hormonal, dietary and pharmacological factors, and is required for cholesterol synthesis and metabolism.

Western blot: 2-4 µg/mL

P07148

Human

A human partial recombinant protein (from within amino acids 1-127 was used as the immunogen for the FABP1 antibody.

FABP1/4518

WB

Protein G affinity

Purified

This FABP1 antibody is available for research use only.

Aliquot the FABP1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide

Optimal dilution of the FABP1 antibody should be determined by the researcher.

Cytoplasm

Western blot testing of human kidney tissue lysate with FABP1 antibody (clone FABP1/4518) . Predicted molecular weight ~15 kDa.