Factor IX (F9) (NM 000133) Humaan Recombinant eiwit

This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Sep 2015]

Purified recombinant protein of Human coagulation factor IX (F9), Val227-End, with N-terminal His-PDCD1 (Pro21-Val170) tag, expressed in E. coli, 50ug

F9 p22; FIX; HEMB; P19; PTC; THPH8

2158

P00740

NM_000133

Xq27.1

E. coli

N-His-PDCD1 (Pro21-Val170)

Complement and coagulation cascades

Complement and coagulation cascades

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.

Druggable Genome, Protease, Secreted Protein

42.9 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

F9

Human

NP_000124

https://www.ncbi.nlm.nih.gov/gene/2158

https://www.uniprot.org/uniprot/P00740

https://www.ncbi.nlm.nih.gov/nuccore/NM_000133

https://www.ncbi.nlm.nih.gov/nuccore/NP_000124