FADD (fosfo Ser191) Antilichaam

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

14082

Q13158

NP_003815.1

Human, Mouse

FADD (phospho Ser191) antibody was raised against a peptide sequence around phosphorylation site of Serine191 (R-S-G (p) -A-M) derived from Human FADD.

Unconjugated

Primary Antibodies

Phospho-Specific , Inflammasomes

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

25 kDa

IgG

The antibody detects endogenous levels of FADD only when phosphorylated at serine 191.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

FADD

Fas (TNFRSF6) -associated via death domain

Homo sapiens

Sugano S., Nat. Genet. 36:40-45 (2004) .

Farmer A., Submitted (MAY-2003) .

Venter J.C., Submitted (JUL-2005) .

MORT1 , FAS-associating death domain-containing protein, Mediator of receptor induced toxicity

WB, IHC

6753812

Liquid