FAK (Ab 576/577) Antilichaam

Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.

5747

Q05397

NP_005598.3

Human, Mouse, Rat

FAK (Ab-576/577) antibody was raised against a peptide sequence around aa.574~578/575~579 (T-Y-Y-K-A) derived from Human FAK.

Unconjugated

Primary Antibodies

Other

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

125 kDa

This antibody detects endogenous level of total FAK protein.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

PTK2

Protein tyrosine kinase 2

Homo sapiens

Parsons, J. T. et al. (2000) Oncogene 19, 5606-5613. Schaller, M. D. et al. (1994) Mol. Cell. Biol. 14, 1680-1688. Chen, H. C. et al. (1996) J. Biol. Chem. 271, 26329-26334. Calalb, M. B. et al. (1995) Mol. Cell. Biol. 15, 954-963.

FAK, FADK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK, JTK2, TKF, FADK 1, PTK2

WB, IHC

27886593

Liquid