FAK (fosfo Ser843) Antilichaam

Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.

5747

Q05397

NP_001186578.1

Human, Mouse, Rat

FAK (phospho Ser843) antibody was raised against a peptide sequence around phosphorylation site of serine843 (R-G-S (p) -I-D) derived from Human FAK .

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

120 kDa

IgG

The antibody detects endogenous level of FAK only when phosphorylated at serine 843.

Western Blot: 1:500~1:1000

PTK2

Protein tyrosine kinase 2

Homo sapiens

Jiang X, Sinnett-Smith J, Rozengurt E (2007) Cell Signal 19, 1000-10 . Jacamo R, Jiang X, Lunn JA, Rozengurt E (2007) J Cell Physiol 210, 436-44. Le Boeuf F, Houle F, Sussman M, Huot J (2006) Mol Biol Cell 17, 3508-20 .

FADK 1, FAK1, Focal adhesion kinase 1, PTK2, pp125FAK

WB

313851044

Liquid