FAK (fosfo Tyr397) Antilichaam

Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Microtubule-induced dephosphorylation at Tyr-397 is crucial for the induction of focal adhesion disassembly. Plays a potential role in oncogenic transformations resulting in increased kinase activity.

5747

Q05397

NP_001186578.1

Human, Rat

FAK (Phospho-Tyr397) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 397 (D-D-Y (p) -A-E) derived from Human FAK.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

125 kDa

This antibody detects endogenous level of FAK only when phosphorylated at Tyrosine 397.

Western Blot: 1:500~1:1000

PTK2

Protein tyrosine kinase 2

Homo sapiens

Matsuya M. et. al. (1998) J. Biol. Chem. 273:1003-1014Fujita H. et. al. (1998) J. Biol. Chem. 273:26516-26521Le Romancer M. et. al. (2008) Mol. Cell 31:212-221

FAK, FADK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK, FAK, PTK2

WB

313851044

Liquid